Methylation Duo
I used to lie awake for hours. Now I can wind down and actually rest. The daytime clarity is an unexpected bonus.
Methyl-Foundations
Methylation Duo
Methylation Duo
Focus
Balance
The Methylation Duo brings together two essentials for feeling balanced from the inside out. Methyl Rise supports energy, focus, and neurotransmitter production, while Mag Drift calms the nervous system and restores mineral balance.
Designed for MTHFR and those sensitive to overstimulation, this pair works synergistically to lift your baseline and bring your body back into steady, sustainable flow.
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Supplement Facts
Vegan
Gluten and Major Allergen Free
No Artificial Colorants
screened for heavy metals
Supplement Facts
Serving Size: 3 vegan Capsules
servings Per Container: 30
servings Per Container: 30
Ingredient
Amount Per Serving
%DV
Folate (L-5-MTHF + Calcium Folinate)
1400 mcg
DFE
DFE
350%
Vitamin B12 (as Methylcobalamin)
750 mcg
31,250%
Vitamin B6 (As Pyridoxal-5-Phosphate)
25mg
1,470%
Riboflavin (As Ribotlavin-5-Phosphate)
5mg
385%
trimethylglycine (TMG)
250mg
†
cordyceps Extract
500mg
†
Gurana Extract (Providing ~60mg caffeine)
750mg
†
Phosphatidylserine (From 200mg)
100mg
†
Lions Mane
400mg
Methylation Duo, At a Glance
benefits
A synergistic daily system supporting the two core pillars of methylation health—activation (Methyl Rise) and restoration (Mag Drift).
- Sharper Focus & Cognitive Clarity – Lion’s Mane, phosphatidylserine, and methylation cofactors support memory, mental stamina, and neurotransmitter balance.
- Steadier Mood & Emotional Resilience – Supports serotonin/dopamine pathways, stress regulation, and calmer nervous system responses.
- Sustained, Gentle Energy – Cordyceps, riboflavin, and bioavailable B12 fuel mitochondrial energy without overstimulation.
- Nervous System Reset & Restful Sleep – Magnesium glycinate/taurinate and Xylaria ease tension, promote relaxation, and support smoother sleep cycles.
- Detox & Cellular Health – Methyl donors and minerals aid homocysteine recycling, liver pathways, and cellular repair.
how to take
A simple rhythm for daily balance.
- Morning — Methyl Rise:
Take 2-3 capsules with or without food to support daytime focus, energy, and methylation function. - Evening — Mag Drift:
Take 2 capsules with or after dinner, or 1–2 extra capsules as needed to support stress relief and sleep quality.
INGREDIENTS
A targeted blend designed for individuals with methylation and nervous system sensitivities.
Methyl Rise
- Methyl Donors & Cofactors – B12, riboflavin, TMG, and active B6 support neurotransmitter synthesis and healthy homocysteine metabolism.
- Lion’s Mane – Supports memory, cognitive clarity, and NGF pathways.
- Cordyceps – Promotes mitochondrial energy and oxygen utilization.
- Phosphatidylserine – Supports cortisol regulation and mental performance.
- Guarana (60 mg caffeine) – Clean, steady alertness.
Mag Drift
- Magnesium (Glycinate, Malate, Taurinate) – Highly bioavailable forms supporting relaxation, metabolic balance, and cardiovascular and neuromuscular regulation.
- Xylaria (Zylaria) – Supports GABA activity, sleep continuity, and emotional balance.
Onset and Expected Results
Everyone’s biology and healing journey is unique. Many people notice shifts in energy, focus, or mood within the first few weeks. Root & Rise supports methylation and cellular pathways at the source, which naturally takes time to restore balance. With steady use, benefits often deepen over 1–3 months, bringing clearer focus, steadier mood, and greater resilience to everyday stress.
Clinical Research
Evidence supporting core ingredients in the duo:
- Lion’s Mane: Shown to improve cognitive performance and support nerve regeneration.
- Cordyceps: Demonstrated improvements in aerobic capacity and cellular ATP production.
- Phosphatidylserine: Associated with reduced stress responses and enhanced memory.
- Magnesium: Systematic reviews show benefits for stress, anxiety reduction, and sleep quality.
- Xylaria: Clinical studies indicate improvements in sleep quality, emotional stability, and nighttime relaxation.
Methylation Essentials for Energy, Mood, and Rest
Energy, Mood, Sleep, and Stress Resilience All Run on One Pathway: Methylation
When methylation slows, you feel it everywhere; low energy during the day, tension at night, and a body that never fully resets. Most people treat these symptoms separately, but they all trace back to one system that most have never heard of.
The Duo restores your 24-hour rhythm: Methyl Rise supports daytime activation, Mag Drift supports nighttime restoration—helping you feel clearer, calmer, and more resilient.
20%
have reduced methylation efficiency affecting energy + sleep
60%
Low mood trace to poor methylation
25%
struggle with nighttime tension from impaired stress-hormone clearance
Methylation Duo was designed for those whose energy and stress struggles trace back to poor methylation
Full-Body Benefits, Backed by Science
Gentle, non-jittery support for energy, focus, and mood, designed specifically for MTHFR.Cognitive Clarity & Memory
Phosphatidylserine + Lion’s Mane support healthy brain cell membranes and synaptic signaling—backing sharper recall, focus, and learning.
Neurotransmitter Balance
Methylated folate and B12 help regulate serotonin, dopamine, and norepinephrine pathways—supporting steadier mood and mental clarity.
Nervous System Support
Riboflavin, P-5-P, and cordyceps work at the cellular level to sustain ATP production and reduce mid-day energy dips.
Detox & Antioxidant Defense
Folate-driven methylation and glutathione recycling help clear toxins and protect cells from oxidative stress.
Cardiometabolic Support
By recycling homocysteine, Root & Rise supports heart and vascular health while reinforcing long-term cellular resilience.
THIRD-PARTY TESTED
heavy metals screened
MICROBIAL & MOLD
no pesticides or solvents
NO FOLIC ACID, DYES, GLUTEN, OR GMOS
THIRD-PARTY TESTED
heavy metals screened
MICROBIAL & MOLD
no pesticides or solvents
NO FOLIC ACID, DYES, GLUTEN, OR GMOS
THIRD-PARTY TESTED
heavy metals screened
MICROBIAL & MOLD
no pesticides or solvents
NO FOLIC ACID, DYES, GLUTEN, OR GMOS
THIRD-PARTY TESTED
heavy metals screened
MICROBIAL & MOLD
no pesticides or solvents
NO FOLIC ACID, DYES, GLUTEN, OR GMOS
THIRD-PARTY TESTED
heavy metals screened
MICROBIAL & MOLD
no pesticides or solvents
NO FOLIC ACID, DYES, GLUTEN, OR GMOS
Our blends by the ingredient:
Product
Methyl Rise
Methyl Rise
Calm & Clear
Mag Drift
- Methylcobalamin (B12)
- L-5-methylfolate
- Cordyceps
- Guarana Extract
- Phosphatidylserine
- Pyridoxal-5-Phosphate (B6)
- Trimethylglycine (TMG/Betaine)
- Riboflavin (Vitamin B2)
- Lion’s mane
Methylcobalamin (B12)
Methylcobalamin is the active, methylated form of B12 used directly in methylation, red blood cell formation, and neurological function. It is particularly important for individuals with MTHFR variants who may struggle to convert standard B12 forms into usable fuel for energy and mood regulation.
L-5-methylfolate
L-5-MTHF is the bioactive form of folate that bypasses the MTHFR enzyme, providing immediate support for DNA repair, methylation balance, and neurotransmitter synthesis. It plays a pivotal role in homocysteine regulation and helps sustain steady mood and cognitive performance.
Cordyceps
Cordyceps is a performance-supportive mushroom shown to enhance ATP production and oxygen utilization at the cellular level. It is commonly used for smooth, stimulant-free energy, improved aerobic capacity, and adrenal balance.
Guarana Extract
Guarana delivers a slow-release source of natural caffeine paired with plant polyphenols that modulate its absorption. This creates a cleaner, longer-lasting lift in alertness and mood without the typical crash associated with synthetic caffeine.
Phosphatidylserine
Phosphatidylserine is a phospholipid concentrated in brain cell membranes. Clinical studies show it supports memory, stress hormone regulation, and cognitive processing by promoting healthy neuronal signaling and cellular repair.
Pyridoxal-5-Phosphate (B6)
P5P is the active form of vitamin B6 required for neurotransmitter synthesis, homocysteine metabolism, and amino acid conversion. It works synergistically with B12 and folate to support mood balance, energy production, and methylation pathways.
Trimethylglycine (TMG/Betaine)
TMG is a key methyl donor that supports healthy homocysteine levels and promotes efficient methylation cycles. It plays an important role in liver function, cellular detoxification, and balanced mood chemistry.
Riboflavin (Vitamin B2)
Riboflavin serves as a cofactor for MTHFR and other enzymes involved in methylation, energy metabolism, and antioxidant defense. It ensures that folate and B12 can be utilized effectively, making it foundational for individuals with genetic methylation impairments
Lion’s mane
Neuro-supportive mushroom linked with nerve growth factors and healthy neuroplasticity; pairs well with B-vitamins for cognitive resilience. Often felt as: clearer recall, “quiet confidence” focus.
Methylcobalamin (B12)
Methylcobalamin is the active, methylated form of B12 used directly in methylation, red blood cell formation, and neurological function. It is particularly important for individuals with MTHFR variants who may struggle to convert standard B12 forms into usable fuel for energy and mood regulation.
L-5-methylfolate
L-5-MTHF is the bioactive form of folate that bypasses the MTHFR enzyme, providing immediate support for DNA repair, methylation balance, and neurotransmitter synthesis. It plays a pivotal role in homocysteine regulation and helps sustain steady mood and cognitive performance.
Cordyceps
Cordyceps is a performance-supportive mushroom shown to enhance ATP production and oxygen utilization at the cellular level. It is commonly used for smooth, stimulant-free energy, improved aerobic capacity, and adrenal balance.
Guarana Extract
Guarana delivers a slow-release source of natural caffeine paired with plant polyphenols that modulate its absorption. This creates a cleaner, longer-lasting lift in alertness and mood without the typical crash associated with synthetic caffeine.
Phosphatidylserine
Phosphatidylserine is a phospholipid concentrated in brain cell membranes. Clinical studies show it supports memory, stress hormone regulation, and cognitive processing by promoting healthy neuronal signaling and cellular repair.
Pyridoxal-5-Phosphate (B6)
P5P is the active form of vitamin B6 required for neurotransmitter synthesis, homocysteine metabolism, and amino acid conversion. It works synergistically with B12 and folate to support mood balance, energy production, and methylation pathways.
Trimethylglycine (TMG/Betaine)
TMG is a key methyl donor that supports healthy homocysteine levels and promotes efficient methylation cycles. It plays an important role in liver function, cellular detoxification, and balanced mood chemistry.
Riboflavin (Vitamin B2)
Riboflavin serves as a cofactor for MTHFR and other enzymes involved in methylation, energy metabolism, and antioxidant defense. It ensures that folate and B12 can be utilized effectively, making it foundational for individuals with genetic methylation impairments
Lion’s mane
Neuro-supportive mushroom linked with nerve growth factors and healthy neuroplasticity; pairs well with B-vitamins for cognitive resilience. Often felt as: clearer recall, “quiet confidence” focus.
- Lion’s mane 2
- Lion’s mane 2
- Lion’s mane 2
Lion’s mane 2
Neuro-supportive mushroom linked with nerve growth factors and healthy neuroplasticity; pairs well with B-vitamins for cognitive resilience.
Often felt as: clearer recall, “quiet confidence” focus.
Often felt as: clearer recall, “quiet confidence” focus.
Lion’s mane 2
Neuro-supportive mushroom linked with nerve growth factors and healthy neuroplasticity; pairs well with B-vitamins for cognitive resilience.
Often felt as: clearer recall, “quiet confidence” focus.
Often felt as: clearer recall, “quiet confidence” focus.
Lion’s mane 2
Neuro-supportive mushroom linked with nerve growth factors and healthy neuroplasticity; pairs well with B-vitamins for cognitive resilience.
Often felt as: clearer recall, “quiet confidence” focus.
Often felt as: clearer recall, “quiet confidence” focus.
Lion’s mane 2
Neuro-supportive mushroom linked with nerve growth factors and healthy neuroplasticity; pairs well with B-vitamins for cognitive resilience.
Often felt as: clearer recall, “quiet confidence” focus.
Often felt as: clearer recall, “quiet confidence” focus.
Lion’s mane 2
Neuro-supportive mushroom linked with nerve growth factors and healthy neuroplasticity; pairs well with B-vitamins for cognitive resilience.
Often felt as: clearer recall, “quiet confidence” focus.
Often felt as: clearer recall, “quiet confidence” focus.
Lion’s mane 2
Neuro-supportive mushroom linked with nerve growth factors and healthy neuroplasticity; pairs well with B-vitamins for cognitive resilience.
Often felt as: clearer recall, “quiet confidence” focus.
Often felt as: clearer recall, “quiet confidence” focus.
- Magnesium Glycinate
- Magnesium Taurinate
Magnesium Glycinate
Neuro-supportive mushroom linked with nerve growth factors and healthy neuroplasticity; pairs well with B-vitamins for cognitive resilience.
Often felt as: clearer recall, “quiet confidence” focus.
Often felt as: clearer recall, “quiet confidence” focus.
Magnesium Taurinate
Neuro-supportive mushroom linked with nerve growth factors and healthy neuroplasticity; pairs well with B-vitamins for cognitive resilience.
Often felt as: clearer recall, “quiet confidence” focus.
Often felt as: clearer recall, “quiet confidence” focus.
Magnesium Glycinate
Neuro-supportive mushroom linked with nerve growth factors and healthy neuroplasticity; pairs well with B-vitamins for cognitive resilience.
Often felt as: clearer recall, “quiet confidence” focus.
Often felt as: clearer recall, “quiet confidence” focus.
Magnesium Taurinate
Neuro-supportive mushroom linked with nerve growth factors and healthy neuroplasticity; pairs well with B-vitamins for cognitive resilience.
Often felt as: clearer recall, “quiet confidence” focus.
Often felt as: clearer recall, “quiet confidence” focus.
I finally broke the cycle of constant exhaustion.
4.8 avg rating, from 2500+ reviews
For years I felt puffy, slow, and reactive to everything. Supporting methylation made a huge difference—I can tell my body is actually clearing things the way it’s supposed to.
Mornings used to feel impossible. Now my mind switches on without the fog or heaviness. It's the first thing that’s given me consistent, sustainable energy.
“My energy spiked within days! I’ve never felt more like myself”
THIRD-PARTY TESTED
heavy metals screened
MICROBIAL & MOLD
no pesticides or solvents
NO FOLIC ACID, DYES, GLUTEN, OR GMOS
Clinical grade because you deserve nothing less
Every lot is heavy-metal screened, GMP-made, NSF certified and batch-traceable with a COA.Your Questions, Answered
Why do these two products work better together than taking just one?
Methylation is a 24-hour cycle with two phases: daytime activation (energy, neurotransmitters, mental clarity) and nighttime restoration (stress-hormone clearance, nervous system recovery, and deep sleep).
Methyl Rise strengthens the activation phase, while Mag Drift supports the restoration phase.
Taken together, they help restore the full rhythm—leading to clearer days, calmer nights, and more consistent energy overall.
How long does it take to feel the benefits of the Duo?
Many people notice improvements in clarity, stress tolerance, and evening relaxation within 1–2 weeks, especially when both products are taken consistently.
Deeper methylation support—better mood, steadier energy, more restorative sleep—typically builds over 4–8 weeks as your biochemical pathways regulate and homocysteine recycling improves.
Can I take the Methylation Duo with coffee, medications, or other supplements?
Yes—most people tolerate the Duo well alongside their current routine.
Methyl Rise pairs well with morning coffee for an even steadier lift, and Mag Drift stacks safely with most evening routines.
If you’re on prescription medications, especially those affecting mood, sleep, or methylation, we recommend checking with your provider.
Who is the Methylation Duo ideal for?
Anyone who struggles with low energy, mood fluctuations, stress sensitivity, restless evenings, or non-restorative sleep—especially if these issues have been long-standing.
It’s also a strong fit for individuals with MTHFR, slow COMT, high stress loads, or poor detox capacity, since both products support the pathway underlying these challenges.