The overlooked gene that impacts energy, mood, detox, and long-term resilience.

Millions of people struggle with unexplained symptoms.
From afternoon crashes to anxious nights — without realizing their genes may be part of the puzzle. The MTHFR gene is a hidden switch that influences how your body makes energy, balances mood, and clears toxins.

Methylation is a biochemical process where tiny “methyl groups” are attached to DNA, proteins, & enzymes.

When methylation runs smoothly, your body feels resilient. When it slows, the cracks show everywhere.

1

DNA REPAIR & EXPRESSION

Supporting line of text
2

Neurotransmitter production

Serotonin, Dopamine, Norepinephrine
3

Detoxification

Alcohol, histamine, and toxins
4

Energy metabolism inside mitochondria

When methylation is impaired, you feel it

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4

Heart health

Roughly 1 in 4 of us has a gene that slows down our methylation, your body’s master switch for energy, and focus, but nobody is addressing it. Otherway was born from my years long search for answers—and a vow that no one else should have to suffer like I did to feel like themselves again.

Heart health

Roughly 1 in 4 of us has a gene that slows down our methylation, your body’s master switch for energy, and focus, but nobody is addressing it. Otherway was born from my years long search for answers—and a vow that no one else should have to suffer like I did to feel like themselves again.

Heart health

Roughly 1 in 4 of us has a gene that slows down our methylation, your body’s master switch for energy, and focus, but nobody is addressing it. Otherway was born from my years long search for answers—and a vow that no one else should have to suffer like I did to feel like themselves again.

Heart health

Roughly 1 in 4 of us has a gene that slows down our methylation, your body’s master switch for energy, and focus, but nobody is addressing it. Otherway was born from my years long search for answers—and a vow that no one else should have to suffer like I did to feel like themselves again.

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MTHFR (methylenetetrahydrofolate reductase) converts dietary folate into methylfolate, the active form your body uses in the methylation cycle.

Folate
Dietary folate from food
MTHFR Enzyme
Converts folate into active 5-MTHF
Uses 5-MTHF + B-12 to recycle homocysteine into methione
Energy
Creates cellular energy
Balanced Homocysteinee
Supports heart & vascular health
Neurotransmitters
Supports mood & focus
Detox & DNA Repair
Clears toxins & repairs cells
Even common MTHFR variants can reduce this enzyme’s efficiency by 30–70%.

Half the population has it, less than 10% know

Up to 50% of people carry MTHFR variants. Yet fewer than 1 in 10 have ever been told about it. That means millions live with fatigue, mood imbalances, or cardiovascular risk without realizing there’s a root cause that can be supporting.

NO VARIANT

Efficient methylation. Your body activates folate normally.

one copy

Mild-Moderate Impact. Slower Enzyme. Symptoms may appear under stress or with poor diet.

TWO copIES

Significant impact. Enzyme efficiency drops 60–70%. Fatigue, mood, & detox issues.

Despite thousands of studies linking MTHFR to cardiovascular disease, depression, miscarriage, and dementia, it’s still not part of standard medical testing.

Many doctors dismiss it, or confuse it with folic acid deficiency — missing the bigger picture of methylation.
Q.

If MTHFR is so common, why are more people struggling now?

The answer lies in the modern world:
Toxins Everywhere
microplastics, pesticides, heavy metals, pollutants
Processed Diets
refined grains, synthetic folic acid, nutrient-depleted foods
Chronic Stress
overwork, poor sleep, constant stimulation
Medication Load
common drugs that deplete methylation cofactors

Our ancestors with the same genes weren’t exposed to this toxic burden. Today’s environment pushes a sluggish methylation cycle past its breaking point.

Not everyone with MTHFR feels symptoms right away. But under the surface, sluggish methylation can silently:

1
Allow homocysteine to build, stressing the heart and vessels
2
Drive low-grade inflammation that accelerates aging
3
Make detox less efficient, leaving toxins to accumulate
4
Increase risk for dementia and neurodegeneration later in life

Experts Agree: MTHFR Matters.

From leading researchers to trusted health voices, the science is converging on one truth: this gene plays a vital role in how your body makes energy, balances mood, and clears toxins, and it’s finally getting the attention it deserves.
“I believe the MTHFR gene mutation is a major public health issue that remains widely overlooked. Millions are affected, through conditions like pulmonary embolisms, addictions, fibromyalgia, miscarriages, schizophrenia, severe depression, cancer, and autism.”
Dr. Ben Lynch
ND
“This is a supplement I use myself everyday to be as healthy as I can, for as long as I can.”
Dr. Mark Hyman
MD
“I believe the MTHFR gene mutation is a major public health issue that remains widely overlooked. Millions are affected, through conditions like pulmonary embolisms, addictions, fibromyalgia, miscarriages, schizophrenia, severe depression, cancer, and autism.”
Dr. Ben Lynch
ND
“No other supplement does what Timeline can. It is an amazing advance for muscle health and longevity.”
Dr. Gabrielle Lyon
MD

MTHFR Foundational Support Protocol

This is your foundation. From here, protocols can be personalized — but these basics help almost everyone with MTHFR.

Add

Key Nutrients
L-5-Methylfolate, Methyl B12, Riboflavin (B2), P5P (B6), Betaine (TMG), Magnesium (glycinate or malate), Choline, and antioxidants (glutathione, CoQ10.)

Food Sources

  • Folate-rich greens (spinach, romaine, avocado)
  • Protein sources with choline and methionine (eggs, salmon, grass-fed beef)
  • Beets and quinoa (natural betaine)
  • Cruciferous vegetables (detox cofactors + sulforaphane)
  • Polyphenol-rich foods (berries, olive oil, green tea)
  • Organ meats

Avoid

Reducemethylation blockers and inflammatory stressors:


  • Synthetic folic acid (fortified breads, cereals)
  • Ultra-processed foods and refined sugars
  • Excess alcohol (depletes methyl donors and B vitamins)
  • Smoking and high toxin load exposure

Lifestyle

Regulate the nervous system and optimize cellular performance:


  • Sleep: Aim for 7–9 hours total, including ~1.5 hours of deep sleep and ~2 hours of REM.


  • Stress Management: Practice HRV-balancing techniques (breathwork, meditation, cold exposure)


  • Light Exposure: 10–15 min of morning sunlight within an hour of waking.


  • Movement: 30 min of daily exercise — ideally alternating resistance training and zone-2 cardio.


  • Hydration & Minerals: 2–3 L of mineral-rich filtered water daily to support detox and methylation balance.

Check Your Methylation Status

Understand your baseline before supplementing:


  • Genetic: MTHFR, COMT, MTR/MTRR, BHMT variants


  • Labs: Genova Methylation Panel or Organic Acids Test


  • Bloodwork: 10–15 min of morning sunlight within an hour of waking.


  • Movement: Homocysteine, Active B12, Folate, B2/B6, Magnesium, heavy metals, Glutathione, C-Reactive Protein


Test, don’t guess — precision starts with data.

Learn the Full Protocol

The first brand to address MTHFR in its full complexity

(Not Just Patch It With B Vitamins)
Explore Our Approach

Otherway integrates all five pillars:

Methylation Foundations
Neurotransmitters & Mood
Detox Pathways
Cellular Energy
Longevity & Resilience
Designed for Sensitivity

Targeted methylation
care in 3 precision blends

Root & Rise

Lab Tested

Root & Rise

Energy & focus for sluggish methylators and MTHFR carriers
Energy
Energy
Focus
Focus
From $152

Mag Drift

Lab Tested

Mag Drift

Grounded focus and steady energy for delicate systems and COMT carriers
Balance
Balance
Sleep
Sleep
From $52

Calm and Clear

Lab Tested

Calm and Clear

Calming magnesium blend + Xylaria mushroom for sleep and stress relief
Focus
Focus
Balance
Balance
From $52

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