No. While our formulas are designed with MTHFR in mind, you don’t need to have MTHFR—or even know your genetics—to benefit.

Methylation affects everyone. Stress, poor sleep, toxins, and nutrient depletion can impair it even without genetic variants.

Yes—absolutely.

You do not need a genetic test to benefit from better methylation support.

Methylation is a foundational process that affects energy production, mood balance, detoxification, hormone metabolism, and brain function. Many people experience symptoms of suboptimal methylation—like fatigue, brain fog, anxiety, low mood, or poor stress tolerance—without knowing their genetic status.

Our formulas are designed to:

• Support methylation gently and intelligently
  
• Avoid common pitfalls like over-methylation
  
• Work for both MTHFR carriers and health-conscious newcomers
  

If you do have MTHFR, these products are designed with you in mind.

If you don’t know yet, they’re a safe, supportive place to start.

Not sure where to begin?

→ Take our “Help Me Choose” quiz to find your best entry point.

This varies by person—but here’s what most people experience:

• Within a few days: subtle shifts in mental clarity, steadier energy, or calmer mood
  
• 1–2 weeks: improved focus, motivation, emotional resilience
  
• 3–6 weeks: deeper changes in baseline energy, stress tolerance, and overall vitality
  

Some people feel changes quickly. Others notice benefits gradually as their system rebalances.

Important note:

If you’ve had negative reactions to methylated supplements in the past, slower is better. Our approach prioritizes tolerance and sustainability, not stimulation.

Most methylation supplements and B-complexes and energy supplements rely on high doses and stimulation to create results. That approach can work, but it often leads to anxiety, crashes, or poor tolerance, especially for people with MTHFR or sensitivity to methylated vitamins (COMT)

Otherway is different because it’s designed to support methylation and cellular energy without overwhelming your system.

• High, but not megadosed (not megadosed)
  
• Built for people who don’t tolerate “standard” B vitamins well
  
• Focused on steady energy, mood balance, and long-term resilience—not spikes
  

Instead of forcing energy, we help your body produce it more efficiently

Not sure if it’s right for you?

→ Take our Methylation Quiz

In most cases, yes—but context matters.

None of the ingredients in our products have known interactions with SSRIs, blood thinners, statins, or other common medications.

In terms of supplements, our products pair well with most other supplements. We wouldn't recommend stacking nootropics with Methyl Rise as that would be redundant.

That said, we recommend checking with your healthcare provider or starting with one product at a time.

Methylation support is often long-term foundational care, especially for MTHFR carriers.

Our products support energy production, nervous system regulation, mood, and detoxification at a root causal level.

While the support you need may decrease as you optimize your methylation, some degree of support will likely be needed in the long term to support optimal health.

While we designed Methyl Rise primarily for those who benefit from methylated vitamins, it does not feature the megadoses found in other methylation supplement and includes phosphatidylserine to soften the stimulation from the brain and energy boosting ingredients.

We designed Methyl Rise intentionally to avoid overstimulation. If you are prone to this, start with one capsule.

We re currently formulating a COMT specific formulation for those with methylated B-vitamin sensitivities. Email our founder at david@otherway.health to share your interest in this product, so we bring it to market faster.

Methylation sits at the intersection of genetics, nutrition, and biochemistry—an area that isn’t deeply covered in conventional medical training.

Most doctors are trained to:

• Diagnose and manage disease
  
• Prescribe medications
  
• Address symptoms once they’re severe
  

Methylation support is more preventive and functional in nature, which is why many people discover it only after years of unexplained symptoms.

Check out our Pathway Blog and MTHFR 101 page to learn more about methylation.

Yes.
There are fortunately many tools to help you assess this, including Genetic Life Hacks, Genetic Genie, Self-Decode, and others.

You don’t need a test to start supporting methylation. Take our Methylation Quiz to see if methylation is contributing to your symptoms.

Methyl Rise is best suited for people experiencing:

• Low or inconsistent energy
• Brain fog or difficulty concentrating
• Low mood or emotional flatness
• Mental fatigue or burnout
• Feeling “off” despite eating well and taking supplements
  

It supports:

• Neurotransmitter balance
  
• Cellular energy production
  
• Healthy methylation flow

Most nootropics rely on stimulants or dopamine-pushing ingredients to create a noticeable effect, but Methyl Rise was designed for those who don't react well to most brain and energy supplements.

Methyl Rise works differently:

• It supports methylation and mitochondrial function
• It helps remove bottlenecks that drain mental energy
• It’s designed for daily use, not short-term performance spikes
  

People often describe the effect as clearer, steadier, and more sustainable rather than intense and buzzy.

This varies, but most people report:

• Subtle mental clarity or energy within a few days
• More consistent focus and mood within 1–2 weeks
• Deeper baseline improvements after 3–4 weeks
  

Methyl Rise is not meant to feel like a “jolt.”

Its value compounds with consistency.

Yes. Methyl Rise is designed for daily, long-term use.

It’s not a stimulant or a short-term cognitive enhancer. Many customers use it as part of their ongoing foundational stack, especially during periods of high cognitive demand or stress.

Some people choose to adjust dosage seasonally or during lower-stress periods, but cycling is not required.

No. While Methyl Rise is designed with MTHFR in mind, you do not need to know your genetics to benefit.

Methylation is affected by stress, toxins, poor sleep, and nutrient depletion—even without genetic variants. Many customers use Methyl Rise simply because they want:

• Cleaner energy
• Better mental performance
• Fewer side effects than typical nootropics

While many people with COMT variants don't react well to methylated B vitamins, others tolerate them just fine.

We designed Methyl Rise to support energy and cognition without intense stimulants and megadose B vitamins. Even our founder who has a COMT variation takes the product without any side effects.

However, we are in the process of developing a COMT version of this product. If you would like to request this product and receive a sample, email care@otherway.health or david@otherway.health

Most people tolerate Methyl Rise well with coffee and a simple supplement stack such as multis, omega-3s, minerals, etc.

We recommend against pairing Methyl Rise with other nootropics to avoid side effects or overstimulation. Cortisol regulating botanicals such as L-theanine and Ashwagandha tend to go well with Methyl Rise.

If you have any questions or concerns, please consult your healthcare provider.

We process orders quickly to get products out as fast as possible. If you need to change or cancel an order, contact our support team as soon as possible. Once an order has shipped, we’re unable to make changes.

If your order hasn’t shipped yet, reach out immediately and we’ll do our best to update it. If the order has already shipped, address changes may not be possible.

Yes. You’ll receive a confirmation email shortly after placing your order, followed by a shipping confirmation with tracking once your order is on its way.

Subscriptions are designed to make consistency easy and provide you with a discount. You’ll receive your product automatically at your chosen interval, with no need to reorder.

You can manage, skip, pause, or cancel your subscription at any time through your account.

Yes—there are no long-term commitments. You can pause, skip, or cancel your subscription at any time before your next shipment.

Yes. You’ll receive an email reminder before each shipment so you’re always in control.

Absolutely. You can update your delivery schedule or swap products directly from your account dashboard.

We currently ship within the continental United States and Canada. International shipping options may be added in the future.

To place an order outside the US or Canada, please contact us so we can help you find a solution at care@otherway.health.

Orders typically ship within 1–3 business days. Once shipped, standard delivery usually takes 3–5 business days, depending on your location.

Shipping costs are calculated at checkout based on your location and order size. Subscription orders may qualify for discounted or free shipping.

Once your order ships, you’ll receive a tracking link via email so you can follow your delivery in real time.

We want you to feel confident trying Otherway. If you’re not satisfied, contact us within 30 days of delivery and we’ll help make it right. No need to return the open bottle.

Because supplements are consumable products, we typically cannot accept returns on opened items.
However, we review requests on a case-by-case basis, especially if something didn’t work as expected.

If your order arrives damaged, defective, or incorrect, contact us right away and we’ll replace it or issue a refund.

Once approved, refunds are typically processed within 5–10 business days and returned to your original form of payment.

Yes. Every Otherway formula is built on established research in methylation, nutrient biochemistry, and nervous system health.

We focus on:

• Bioavailable forms of nutrients
• Clinically relevant (not excessive) dosing
• Synergistic combinations that work together, not in isolation
• Patented ingredients with clinical testing
  

Clinical studies on each of the ingredients we include can be found on our product pages in the "At a Glance" section.

Yes. All ingredients are sourced from reputable suppliers and tested to meet strict quality and safety standards.

Our products are manufactured in facilities that follow cGMP (Current Good Manufacturing Practices).

No. We avoid artificial colors, unnecessary fillers, and low-quality excipients whenever possible.

Our formulations are intentionally clean, functional, and designed to support absorption and tolerance.

I’m sensitive to B-vitamins and stimulants—will I feel wired?

Can I take this with my current meds or supplements?

Yes. We partner with select retailers, practitioners, and aligned brands who share our commitment to thoughtful, education-driven wellness.

We prioritize partnerships that value quality, integrity, and long-term customer outcomes over volume alone.

Contact care@otherway.health to start the process.

Otherway is a strong fit for:

• Health-forward retailers and boutiques
• Functional medicine, integrative, or mental health practitioners
• Wellness spaces focused on education and trust
  

If your audience includes people dealing with fatigue, brain fog, mood imbalance, or supplement sensitivity, there’s likely alignment.

Yes. Education is core to our mission.

We offer partners:

• Product education and positioning support
  
• Clear guidance on who each formula is for
  
• Access to science-forward resources to help customers make informed decisions

Wholesale terms, including minimums and opening orders, vary depending on the partnership. Our team will walk you through options once we understand your needs and goals.