Root & Rise

Sharper Focus – Phosphatidylserine, Lion’s Mane, and methylation cofactors promote clearer thinking and memory.

Built with MTHFR in mind – Formulated for those with genetic or lifestyle challenges in methylation—closing the gaps multis and nootropics miss.

Steadier Mood – Supports serotonin and dopamine balance for fewer spikes and crashes.

Sustained Energy – Bio-available B12, riboflavin, and cordyceps fuel mitochondrial energy production.

Detox & Cellular Health – Active folate and glutathione recycling aid homocysteine balance and resilience..

Take 3 Capsules preferably with water. For optimal results, consume the supplement in the morning with your breakfast or as advised by your healthcare professional.

Methylfolate (L-5-MTHF)
The most advanced, clinically studied form of methylfolate. Supports methylation, neurotransmitter balance, and homocysteine recycling for long-term cellular health.

Methylcobalamin (B12)
Active, bioavailable B12 that fuels energy production and works synergistically with folate for optimal methylation support.

P-5-P (Active B6)
The coenzyme form of vitamin B6, critical for neurotransmitter synthesis, homocysteine metabolism, and stress resilience.

Trimethylglycine (Betaine)
TMG is a key methyl donor that supports healthy homocysteine levels and promotes efficient methylation cycles. It plays an important role in liver function, cellular detoxification, and balanced mood. 

Lion’s Mane Mushroom
A nootropic adaptogen that promotes nerve growth factor (NGF), memory, and cognitive clarity.

Cordyceps Mushroom
An adaptogen that supports mitochondrial energy, oxygen utilization, and resilience under stress.

Other Ingredients

Riboflavin (B2), Phosphatidylserine, Guarana extract

VIEW SUPPLEMENT facts

Everyone’s biology and healing journey is unique. Many people notice shifts in energy, focus, or mood within the first few weeks. Root & Rise supports methylation and cellular pathways at the source, which naturally takes time to restore balance. With steady use, benefits often deepen over 1–3 months, bringing clearer focus, steadier mood, and greater resilience to everyday stress.

There are 5 credible reviews and studies related to this product:

• Folate, Homocysteine, and Neuropsychiatric Disorders: Review linking methylfolate supplementation with improved mood and cognitive outcomes.

• Comparison of Quatrefolic® and Folic Acid: Clinical trial showing superior bioavailability and homocysteine reduction with methylfolate.

• Vitamin B6 (P-5-P) in Neurotransmitter Metabolism: Evidence that active B6 supports serotonin, dopamine, and stress resilience.

• Lion’s Mane Mushroom and Cognitive Function: Randomized controlled trial reporting improved memory and focus via NGF stimulation.

• Cordyceps and Exercise Performance: Human studies showing increased oxygen efficiency, ATP production, and reduced fatigue.

• Phosphatidylserine and Cognitive Health: Double-blind trials demonstrating benefits for working memory, focus, and cortisol balance.

Most energy and focus products rely on stimulants or megadoses that push your system hard and leave you crashing later. MethylRise takes a different approach.

It works at the cellular level—supporting methylation, mitochondrial function, and neurotransmitter balance so your body can produce steady, clean energy on its own.

We pair gentle, bioactive B-vitamins with clinical nootropics like Lion’s Mane, Cordyceps, and phosphatidylserine to lift cognitive clarity without overstimulation. The result is focus and vitality that feel natural, calm, and sustainable.

No. MethylRise was developed specifically for people who are sensitive to typical B-complexes, caffeine-heavy stacks, and high-stim nootropics.

We avoid megadoses and use a balanced combination of methyl and hydroxy B12, folate in its active form, and botanicals that promote focus without pushing the nervous system.

Expect calm clarity—not adrenaline. It’s designed to sharpen your mind while keeping your body steady.

Many individuals notice a shift within 1–7 days—cleaner energy, better concentration, and fewer dips in the afternoon.

Benefits continue to build as methylation pathways normalize:

• Weeks 1–2: clearer focus, improved cognitive stamina
  
• Weeks 3–4: more stable mood and motivation
  
• 8–12 weeks: deeper mitochondrial support, reduced brain fog, and more consistent mental sharpness
  
  Methyl Rise is formulated for both immediate support and long-term cellular renewal.

MTHFR variants and slow-COMT profiles often struggle with unstable energy, poor detox efficiency, and sensitivity to standard B-vitamins.

MethylRise is designed around these needs. It includes:

• Active folate (not folic acid) to bypass genetic bottlenecks
  
• Bioavailable B12 (methylcobalamin) for balanced methylation support
  
• Botanicals and cofactors that stabilize neurotransmitter activity
  
• Gentle, physiologic dosing to avoid overstimulation
  
  If you’ve reacted poorly to traditional B-complexes or stimulant-based nootropics, Methyl Rise offers a more predictable, supportive alternative.

Yes. Methyl Rise pairs well with most morning routines.

You can take it alongside coffee for a smoother, more grounded focus curve, and it complements magnesium, omega-3s, and adaptogens.

If you’re already using a high-dose B-complex or a stimulant-based nootropic, you may not need both—MethylRise often replaces multiple products in a stack.

If you’re taking prescription medications for mood or attention, consult your clinician to personalize timing.

The experience is typically described as a clean, calm lift.

Not a buzz, not a spike—just sharper thinking, easier motivation, and a more organized mental landscape. Many people notice fewer dips in mental energy and a more stable rhythm throughout the day.

Because the formula supports cellular pathways rather than overstimulating neurotransmitters, the clarity feels grounded and sustainable—not jittery or intense.

The goal is simple: to help you feel like your most focused, functional self again.