Methyl-Foundations

DNA Testing Kit

DNA Testing Kit

Designed specifically for MTHFR, this advanced nootropic blend offers comprehensive methylation support to promote sharper focus, steadier mood, and sustained energy without overstimulation. 

Support neurotransmitter balance and mental clarity
Promote resilience against stress and emotional swings
Mitochondrial function for all-day vitality
Powerful foundational support for MTHFR

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Supplement Facts

Vegan

Gluten and Major Allergen Free

No Artificial Colorants

screened for heavy metals

Supplement Facts

Serving Size: 3 vegan Capsules
servings Per Container: 30

Ingredient

Amount Per Serving

%DV

Folate (L-5-MTHF + Calcium Folinate)

1400 mcg
DFE

350%

Vitamin B12 (as Methylcobalamin)

750 mcg

31,250%

Vitamin B6 (As Pyridoxal-5-Phosphate)

25mg

1,470%

Riboflavin (As Ribotlavin-5-Phosphate)

5mg

385%

trimethylglycine (TMG)

250mg

†

cordyceps Extract

500mg

†

Gurana Extract (Providing ~60mg caffeine)

750mg

†

Phosphatidylserine (From 200mg)

100mg

†

Lions Mane

400mg

Root & Rise,  At a Glance

benefits

Addresses the root cause of fatigue in those with MTHFR
Balanced mood without overstimulation
Sharper recall & focus
Cellular detox & energy support

how to take

Take 3 Capsules preferably with water. For optimal results, consume the supplement in the morning with your breakfast or as advised by your healthcare professional.

INGREDIENTS

INGREDIENT 01

Directly fuels DNA repair & neurotransmitter synthesis — critical for MTHFR carriers.

INGREDIENT 02

Directly fuels DNA repair & neurotransmitter synthesis — critical for MTHFR carriers1.

INGREDIENT 03

Directly fuels DNA repair & neurotransmitter synthesis — critical for MTHFR carriers1.

Other Ingredients:

Riboflavin (B2), Phosphatidylserine, Magnesium, Trimethylglycine (TMG), N-Acetylcysteine (NAC), Glutathione precursors, and additional cofactors to round out full-pathway methylation and cellular support.

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Onset and Expected Results

Everyone’s biology and healing journey is unique. Many people notice shifts in energy, focus, or mood within the first few weeks. Root & Rise supports methylation and cellular pathways at the source, which naturally takes time to restore balance. With steady use, benefits often deepen over 1–3 months, bringing clearer focus, steadier mood, and greater resilience to everyday stress.

Clinical Research

There are 5 credible reviews and studies related to this product:

Folate, Homocysteine, and Neuropsychiatric Disorders: Review linking methylfolate supplementation with improved mood and cognitive outcomes. 
Comparison of Quatrefolic® and Folic Acid: Clinical trial showing superior bioavailability and homocysteine reduction with methylfolate. 
Vitamin B6 (P-5-P) in Neurotransmitter Metabolism: Evidence that active B6 supports serotonin, dopamine, and stress resilience. 
Lion’s Mane Mushroom and Cognitive Function: Randomized controlled trial reporting improved memory and focus via NGF stimulation. 
Cordyceps and Exercise Performance: Human studies showing increased oxygen efficiency, ATP production, and reduced fatigue. 
Phosphatidylserine and Cognitive Health: Double-blind trials demonstrating benefits for working memory, focus, and cortisol balance.

You’re Not Alone: 1 in 5 Can’t Methylate Well

Most people have never heard of methylation, the process that powers detox, neurotransmitter balance, and energy production. Yet nearly 20% of us struggle with it, leading to persistent brain fog, low energy, and mood challenges that conventional approaches miss. We are here to change that.

25%

Can’t convert
Folic Acid

60%

Low mood trace to poor methylation

25%

Can’t clear
stress hormones

Root & Rise was designed for those whose energy and mood struggles trace back to poor methylation

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Full-Body Benefits, Backed by Science

Gentle, non-jittery support for energy, focus, and mood, designed specifically for MTHFR.

Cognitive Clarity & Memory

Phosphatidylserine + Lion’s Mane support healthy brain cell membranes and synaptic signaling—backing sharper recall, focus, and learning.

Neurotransmitter Balance

Methylated folate and B12 help regulate serotonin, dopamine, and norepinephrine pathways—supporting steadier mood and mental clarity.

Nervous System Support

Riboflavin, P-5-P, and cordyceps work at the cellular level to sustain ATP production and reduce mid-day energy dips.

Detox & Antioxidant Defense

Folate-driven methylation and glutathione recycling help clear toxins and protect cells from oxidative stress.

Cardiometabolic Support

By recycling homocysteine, Root & Rise supports heart and vascular health while reinforcing long-term cellular resilience.

STACKING TIP

Pair with Mag Drift at night
for deep detox support

Mag Drift

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A new standard in methylation support

Methylation touches everything from neurotransmitters to detox and energy. We combine bioavailable B-vitamins with neuro and mitochondria supportive botanicals so you feel the lift.

METHYLFOLATE
Methylcobalamin
CoQ10
Pyridoxal-5-Phosphate
Cordyceps Extract
LION’S MANE
Guarana

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